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Most severe symptoms reported by MPN patients by disease

MPN stands for myeloproliferative neoplasms, a group of rare blood cancers that affect the production of blood cells in the bone marrow. MPN patients often experience various symptoms affecting their quality of life and daily functioning.





This blog post will look at some of the most severe symptoms reported by MPN patients by disease type.


Polycythemia vera (PV) is a type of MPN that causes the bone marrow to make too many red blood cells, which can lead to blood clots, strokes, and heart attacks. Some of the most severe symptoms reported by PV patients are:

  • Headaches

  • Dizziness

  • Fatigue

  • Itching

  • Vision problems

  • Abdominal pain

  • Gout


Essential thrombocythemia (ET) is a type of MPN that causes the bone marrow to make too many platelets, leading to blood clots and bleeding problems. Some of the most severe symptoms reported by ET patients are:

  • Headaches

  • Dizziness

  • Chest pain

  • Numbness or tingling in the hands or feet

  • Bruising or bleeding easily

  • Splenomegaly (enlarged spleen)


Myelofibrosis (MF) is a type of MPN that causes the bone marrow to become scarred and fibrous, which impairs its ability to produce blood cells. Some of the most severe symptoms reported by MF patients are:

  • Anemia (low red blood cell count)

  • Fatigue

  • Weakness

  • Shortness of breath

  • Night sweats

  • Fever

  • Weight loss

  • Splenomegaly (enlarged spleen)

  • Bone pain


MPN patients may experience different symptoms depending on their disease type, stage, and treatment. MPN patients must monitor their symptoms and report any changes to their doctor. Treatments are available to help manage MPN symptoms and reduce the risk of complications.


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